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Study finds cancer cells break down protective nerve coverings, leading to nerve injury and chronic inflammation These nerve injuries drive immune exhaustion and immunotherapy resistance Targeting the cancer-induced nerve injury pathway can reverse resistance and improve treatment response Findings highlight importance of studying cancer neuroscience – the interactions between cancer and the nervous system

Cancer cells can break down...

Phase I trial demonstrates lasting responses and encouraging safety profile in two aggressive thyroid cancer subtypes, suggesting further progress for CAR T cell therapy in solid tumors One patient experienced a complete response, and one patient had a partial response This type of cancer has limited treatment options, and most patients have a poor prognosis of six months or less AIC100 is a CAR T cell therapy that targets the ICAM-1 protein...